Annovis Bio, Inc. Common Stock (ANVS)

Researchers studying brain waves have suggested that a new discovery they have made could hold the key to treating anxiety in people diagnosed with Parkinson’s disease . For a long time, DBS ( deep brain stimulation ) has been leveraged in the management of the physical symptoms linked to Parkinson’s, such as tremor, slowness and body stiffness. This new research suggests that DBS can take advantage of a specific brain wave and help treat anxiety in those with Parkinson’s disease.

Annovis Bio (NYSEANVS) will host a live webcast on Feb. 27, 2025, at 4:30 p.m. EST, where CEO Maria Maccecchini, Ph.D., will answer questions from patients, caregivers, and families regarding the company’s clinical trials and future plans. The forum will provide updates on the ongoing Phase 3 Alzheimer’s disease trial, plans for the Phase 3 Parkinson’s disease study, and patient communication strategies. A brief presentation will precede a Q&A session, with attendees encouraged to submit questions in advance. The event underscores Annovis’ commitment to patient engagement and transparency.

An ongoing clinical trial aims to test a drug that is hoped to avert Alzheimer’s disease decades before it is expected to manifest in an individual. This study is being conducted by a team at the School of Medicine at Washington University.

Annovis Bio (NYSEANVS) a late-stage clinical drug platform company developing therapies for neurodegenerative diseases, announced that CEO Maria Maccecchini, Ph.D., will present at Oppenheimer’s 35th Annual Healthcare Life Sciences Conference on Feb. 11, 2025, from 12:40 to 1:10 p.m. ET. The virtual presentation will cover the company’s progress on its pivotal Phase 3 trial for early Alzheimer’s disease and strategic plans for a New Drug Application for buntanetap. The conference gathers industry leaders and investors to discuss key innovations and market trends in healthcare and life sciences.

Annovis Bio (NYSEANVS) announced that the first two patients have been enrolled in its pivotal Phase 3 trial evaluating buntanetap for early Alzheimer’s disease. The randomized, placebo-controlled study will assess the drug’s symptomatic and potential disease-modifying effects over 18 months. Following positive Phase 2/3 results, the trial received FDA approval and aims to enroll over 750 participants across approximately 100 U.S. sites. The company recently secured $21 million in funding to support the initial six-month phase, with the remaining study expected to be funded through warrant exercises.

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Annovis Bio (NYSEANVS), a late-stage clinical drug company focused on neurodegenerative diseases, announced the closing of its underwritten public offering, raising $21 million in gross proceeds. The offering included 5.25 million shares of common stock and warrants at a combined price of $4.00 per share, with warrants exercisable at $5.00 per share for five years. The company plans to use the funds primarily for the continued Phase 3 development of its lead Alzheimer’s drug, Buntanetap, as well as for working capital and corporate purposes. ThinkEquity acted as the sole book-running manager.

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Annovis Bio (NYSEANVS), a late-stage clinical drug platform company developing treatments for neurodegenerative diseases, has priced an underwritten public offering of 5.25 million shares of common stock and warrants at a combined price of $4 per share. The warrants, exercisable at $5 per share for five years, are expected to generate gross proceeds of $21 million before deducting expenses. ThinkEquity is the sole book-running manager. The offering is set to close Feb. 4, 2025, subject to customary conditions, with proceeds primarily allocated to working capital and further clinical development of its lead drug candidate, Buntanetap.

Last week, the National Institutes of Health announced that it had begun the process of implementing the Dr. Emmanuel Bilirakis and Honorable Jennifer Wexton National Plan to End Parkinson’s Act, with support from the Health and Human Services department. This legislation was signed into law on July 2 nd , 2024, and directs that the Secretary of Health and Human Services conduct a project to prevent, diagnose, treat and cure Parkinson’s disease.

Annovis Bio (NYSEANVS), a late-stage clinical drug platform company, has received a U.S. patent for methods using buntanetap to treat and prevent acute brain and nerve injuries. The patent, issued on Jan. 2, 2025 (US-2025-0000846-A1), covers buntanetap’s ability to reduce neurotoxicity and mitigate neurodegenerative processes in conditions such as stroke, ischemia, traumatic brain injury, and micro infarcts. Already patented in the EU, Japan, and globally, this approval enhances Annovis’ intellectual property portfolio. CEO Maria Maccecchini, Ph.D., emphasized buntanetap’s potential to protect and restore neuronal health, expanding its applications beyond Alzheimer’s and Parkinson’s disease.

Annovis Bio (NYSEANVS), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases such as Alzheimer’s disease (“AD”) and Parkinson’s disease (“PD”), today announced that the FDA has accepted an updated protocol for the pivotal Phase 3 AD study, which is slated to begin in January 2025. In October 2024, the FDA granted clearance for Annovis to proceed with the pivotal Phase 3 AD studies based on its Phase 2/3 data demonstrating cognitive improvement in early-stage AD patients. The original protocol design proposed two separate trials that are now integrated into a single 6/18-month trial under the revised protocol.

Annovis Bio (NYSEANVS), a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases, was featured in a recent article that discussed the company’s year-end investor webcast, where it provided stakeholders with a comprehensive overview of 2024 milestones and strategic initiatives for 2025. The webcast also highlighted financial developments, including the securing of a $50 million At-The-Market (“ATM”) offering and ongoing strategic efforts to raise additional funds to support clinical trial development and long-term growth.

Annovis Bio (NYSEANVS) is a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases. The company’s lead candidate, buntanetap, is an innovative drug that targets multiple pathways involved in neurodegenerative diseases by inhibiting the production of neurotoxic proteins that lead to the death of neurons, thereby slowing or stopping disease progression. A recent article highlights the company’s successful clinical trials and its receipt of FDA clearance to proceed with a pivotal phase 3 Alzheimer’s disease program for buntanetap, set to begin in early 2025.

Annovis Bio (NYSEANVS) is a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases, such as Alzheimer’s (“AD”) and Parkinson’s (“PD”). The company concluded the third quarter with the completion of significant milestones and a clear path forward for its lead candidate, buntanetap. “Buntanetap is an innovative drug designed to target neurodegeneration by inhibiting the formation of multiple neurotoxic proteins, including amyloid beta, tau, alpha-synuclein and TDP43,” reads a recent article. “This multifaceted inhibition improves synaptic transmission and axonal transport, reduces neuroinflammation, and protects nerve cells from dying, positioning buntanetap as a potential breakthrough in treating neurodegenerative diseases.”

Annovis Bio (NYSEANVS), a clinical-stage drug platform company pioneering transformative therapies for neurodegenerative diseases, recently hosted its Year-End Investor Webcast, providing stakeholders with a comprehensive overview of the company’s 2024 milestones and strategic initiatives for 2025. The full webcast is available here: https://youtu.be/NA3kCUZZIpI .

In the early stages of Parkinson’s disease, alpha-synuclein accumulates in the brain, damaging nerve cells that produce dopamine. Dopamine is a hormone that regulates movement. Its absence in the brain can cause movement problems, among other symptoms.

LOS ANGELES, Dec. 05, 2024 (GLOBE NEWSWIRE) -- via IBN -- InvestorBrandNetwork, a multifaceted communications organization engaged in connecting public companies to the investment community, is pleased to announce Annovis Bio’s (NYSEANVS) recent feature on Today’s Marketplace (TMP) as part of its commitment to amplifying industry leaders’ voices through targeted distribution channels.

Annovis Bio (NYSEANVS), a leader in developing treatments for neurodegenerative diseases, was recently featured on Today’s Marketplace in an exclusive interview with Dr. Maria Maccecchini, Founder, President, and CEO. Dr. Maccecchini detailed Annovis Bio’s groundbreaking drug development targeting toxic proteins responsible for nerve cell damage in Alzheimer’s and Parkinson’s, as well as the company’s next-phase clinical trials. Emphasizing the broader impact of these diseases on caregivers as well as patients, Dr. Maccecchini shared insights into the meaningful progress Annovis Bio is making. The Today’s Marketplace feature continues to spotlight Annovis Bio’s leadership in addressing critical healthcare challenges, reinforcing its commitment to innovation and improving lives.

Annovis Bio (NYSEANVS) was featured in an interview with Today’s Marketplace (“TMP”). The company’s Founder, President and CEO, Maria Maccecchini, PHD, and Scott Shipman, MD, MPH, Executive Director for Creighton University’s Institute for Population Health, joined host Jane King to discuss clinical trials of a new drug that is showing promise for the treatment of neurodegenerative diseases like Alzheimer’s (“AD”) and Parkinson’s (“PD”) and their impact on population health.

Annovis Bio (NYSEANVS), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases such as Alzheimer’s disease (“AD”) and Parkinson’s disease (“PD”), will hold a live investor webcast on Dec. 11, 2024, at 4:30 p.m. EST, to provide key operational highlights and year-end clinical updates ( https://ibn.fm/69VpQ ).

Annovis Bio (NYSEANVS), a clinical-stage company developing therapies for neurodegenerative diseases, will host a live investor webcast on Dec. 11, 2024, at 4:30 PM EST. Led by Founder and CEO Dr. Maria Maccecchini, the event will highlight updates on Phase 3 studies for Parkinson’s and Alzheimer’s diseases, regulatory milestones, financial strategies, and plans for advancing neurodegenerative therapies in 2025.